Director, Ingestive Behavior and Obesity Program, Oppenheimer Center for Neurobiology of Stress; Division of Digestive Diseases, David Geffen School of Medicine at UCLA
Claudia Sanmiguel is the Ingestive Behaviors and Obesity Program (IBOP) director at the Oppenheimer Center for Neurobiology of Stress (CNS) and she is a clinical instructor at the UCLA Digestive Diseases Division. She was born in Bogota, Colombia where she studied Medicine at the Pontificia Universidad Javeriana and specialized in Internal Medicine and Gastroenterology. Then she moved to Alberta, Canada where she did research on gastrointestinal motility and the use of artificial pacemakers and stimulators for the treatment of gastrointestinal disorders. She continued her research career at the Cleveland Clinic in Ohio and at the Cedars Sinai Medical Center in Los Angeles, where she explored the use of pacemakers and electrical stimulators for the treatment of obesity and obesity related diabetes mellitus, as well as, studied gastric electromechanical signals related to eating behavior and satiety. As part of pursuing a research career in United States, she completed her residency in Internal Medicine at Cedars-Sinai Medical Center and trained in Gastroenterology at the University of California Los Angeles. She has continued her pursue on understanding the mechanisms that regulate eating behavior in health and in obesity, and the role of the brain/gut/microbiome axis in interpreting and regulating those behaviors. She has published several papers in well known GI and bioengineering journals and presented her research results in North American and International meetings. She currently has partial NIH funding for a study on the role of brain activity and changes in eating behavior in weight loss after bariatric surgery and how some peripheral signals coming from visceral fat and gut microbiome may play a role in obesity and weight loss. She is also doing research on neuroplasticity in brain areas related to eating hehaviors in response to neuromodulation.
Recent Relevant Publications
Sanmiguel C, Gupta A, Mayer EA. Gut Microbiome and Obesity: A Plausible Explanation for Obesity. Curr Obes Rep. 2015 Jun;4(2):250-261.
Sanmiguel CP, Gupta A, Labus LS, Coveleskie K, KaragiannidisI , AlaverdyanM, Ashe-McNalley C, Stains J, and others. Adiposity Is Associated With Alterations Within the Brain Reward System in Adult Subjects. Gastroenterology 2015, Vol. 148, Issue 4, S-674
Gupta A, Mayer EA, Sanmiguel CP, Van Horn JD, Woodworth D, Ellingson BM, Fling C, Love A, Tillisch K, Labus JS. Patterns of Brain Structural Connectivity Differentiate Lean from Overweight Subjects. Neuroimage-Clinical, 2015; 7: 506–517.
Sanmiguel CP, Coveleskie K, Gupta A, Kilpatrick L, Labus J, Ashe-McNalley C, Dutson EP, Mayer EA. Association of abdominal fat with resting state low frequency brain activity in human subjects. Neurogastroenterology & Motility. 2013; 25, Suppl 1:14
Sanmiguel CP, Ito Y, Hagiike M, Conklin JL, Lalezari D, Soffer EE. The effect of eating on Lower Esophageal Sphincter electrical activity. American Journal of Physiology Gastrointest Liver Physiology. 2009 Apr; 296(4): G793-797.
Sanmiguel CP, Conklin JF, Cunneen SA, Barnett P, Phillips EH, Kipnes M, Pilcher J, Soffer EE. Gastric Electrical Stimulation with the TANTALUS® System in Obese Type 2 Diabetes Patients: Effect on Weight and Glycemic Control. J Diabetes Science and Technology. 2009; 3: 964-970
Sanmiguel CP, Haddad W, Aviv R, Cunneen SA, Phillips EH, Kapella W, Soffer EE. The TANTALUS TM System for obesity: effect on gastric emptying of solids and ghrelin plasma levels. Obes Surg. 2007; 17: 1503-9.
Aviv R, Policker S, Brody F, Bitton O, Haddad W, Kliger a, Sanmiguel CP, Soffer EE. Circadian patterns of gastric electrical and mechanical activity in dogs. Neurogastroenterol Motil. 2008; 20:63-8
Aviv R, Sanmiguel CP, Kliger A, Policker S, Haddad W, Hagiike M, Soffer EE. The use of gastric electrical signals for algorithm for Automatic Eating Detection in dogs. Neurogastroenterol Motil.; 2008, 20:369-76.