Photo of Wenyuan Shi, PhD
Wenyuan Shi, PhD
Professor and Chairman, Oral Biology, UCLA School of Dentistry Professor, Microbiology and Molecular Genetics, UCLA School of Medicine Founding scientist and chief science officer, C3 Jian Inc.

Home 10833 Le Conte Avenue Los Angeles CA 90095-1668 Phone: (310) 825-8356Fax: (310) 794-7109

Dr. Wenyuan Shi is a chairman and professor of Oral Biology at UCLA Schools of Dentistry. Dr. Shi’s laboratory has been using multidisciplinary approaches to study oral microbial pathogenesis with a specific focus on microbial biofilm, inter-species interaction and signal transduction. In addition, Dr. Shi’s laboratory is actively involved in the development of next generation of diagnostic and therapeutic tools against oral microbial infections, including instant chairside detection of oral pathogens and peptide based targeted antimicrobial therapeutics. These translational research efforts have resulted in novel technologies that are licensed and developed by major pharmaceutical, dental and biotech companies. Dr. Shi is also the founding scientist, chief science officer, and chairman of the scientific advisory board of C3 Jian Inc. (

Dr. Shi obtained his BS degree from Fudan University (Shanghai) in 1984, acquired his Ph.D degree from University of Wisconsin-Madison in 1991 and fulfilled his postdoctoral training at University of California-Berkeley during 1992-1995. He is co-author and co-inventor of over 200 scientific articles and patents.

Relevant Recent Publications

  1. He, X., T. Yan, L. Guo, R. Lux, D. R. Zusman and W. Shi. 2010. In vitro communities derived from oral and gut microbial floras inhibit the growth of bacteria of foreign origins. Microbial Ecology. 60(3):665-76 PMCID: PMC2954289
  2. He, X., T. Yan, L. Guo, R. Lux, D. R. Zusman and W. Shi. 2010. Oral-derived bacterial flora defends its domain by recognizing and killing intruders—a molecular analysis using Escherichia coli as a model intestinal bacterium. Microbial Ecology. 60(3):655-64 PMCID: PMC2954290
  3. He, X., W. Hu, J. He, H. Guo, R. Lux and W. Shi. 2011 Community-based interference against of human integration of Pseudomonas aeruginosa into human salivary microbial biofilm. Molecular Oral Microbiology. 26: 1-16. PMCID:PMC3327514
  4. He, X., J. McLean, L. Guo, R. Lux and W. Shi 2013. The social structure of microbial community involved in colonization resistance. The ISME Journal 8(3):564-74. PMCID:PMC3930314

Active Funding in Microbiome-Related Research

Funding Agency/Grant Number:NIH NIDCR 1R01DE023810
Title:“Domestication and characterization of TM7-the most elusive oral phylum”
Funding Agency/Grant Number:NIH NIDCR 1-R01-DE020102
Title:“Making a quantum leap in plaque research with modern sciences”
Funding Agency/Grant Number:NIH NIDCR 1-R01-DE021108
Title:“Molecular analysis of F. nucleatum interspecies interactions in biofilms”
Funding Agency/Grant Number:NIH NIGMS 1 R01 GM095373
Title:“Moving beyond diversity by revealing biological functions of uncultured bacteria”

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