Photo of David Walker, PhD
David Walker, PhD
Professor, Department of Integrative Biology and Physiology, UCLA

Dr. Walker is a Professor in the department of Integrative Biology and Physiology at the University of California, Los Angeles (UCLA). He is also a faculty member of the Molecular Biology Institute at UCLA. Dr. Walker completed his Ph.D. degree at the University of Manchester, UK. He then went on to carry out postdoctoral work with Seymour Benzer at the California Institute of Technology. He joined the faculty at UCLA as an Assistant Professor in 2007 and was promoted to Associate Professor in 2012 and full Professor in 2015. Dr. Walker has a long-standing interest in the biological mechanisms of aging. In recent years, his research group has made important insights into the relationship between intestinal aging and organismal aging. In this work, Dr. Walker is exploring the relationships between age-related changes in microbiota composition, intestinal physiology and the health and viability of the aging host organism.

Dr. Walker is the recipient of several awards, including an Ellison Medical Foundation New Scholar in Aging award as well as a Career Development Award from the UCLA Older Americans Independence Center. Most recently, Dr. Walker is the recipient of a Julie Martin Mid-Career Award in Aging Research from the American Federation for Aging Research (AFAR).

Relevant Recent Publications:

  1. Clark, R.I., Salazar, A, Yamada, R, Fitz-Gibbon, S, Morselli, M, Alcaraz, J, Rana, A, Rera, M, Pelligrini, M, Ja, WW, Walker. D.W. (2015) Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality. Cell Reports (in press)
  2. Ulgerhait, M, Rana, A, Rera, M, Graniel, J, Walker D.W. (2014) AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. Cell Reports 8: (6), p1767–1780.
  3. Rera, M, Clark, R.I., Walker D.W. (2012) Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci USA 109(52): 21528-33.
  4. Rera, M, Bahadorani S, Cho J, Koehler, C, Hur, JH, Ulgerhait, M, Jones, DL, Walker DW. (2011). Modulation of longevity and tissue homeostasis by the Drosophila homolog of PGC-1. Cell Metabolism 14(5):623-34

Active Funding in Microbiome-Related Research

Funding Agency/Grant Number:NIH 1R01AG049157
Title:“Role of Intestinal Homeostasis in Organismal Aging”
Photo of Paul Weiss, PhD
Paul Weiss, PhD
UC Presidential Chair; Distinguished Professor of Chemistry & Biochemistry and of Materials Science & Engineering; ACS Nano Editor-in-Chief

Paul S. Weiss holds a UC Presidential Chair and is a distinguished professor of chemistry & biochemistry and of materials science & engineering at UCLA. He received his S.B. and S.M. degrees in chemistry from MIT in 1980 and his Ph.D. in chemistry from UC Berkeley in 1986. He was a postdoctoral member of technical staff at Bell Laboratories from 1986-88 and a visiting scientist at IBM Almaden Research Center from 1988-89. He served as the director of the California NanoSystems Institute and held the Fred Kavli Chair in NanoSystems Sciences at UCLA from 2009-2014. Before coming to UCLA, he was a distinguished professor of chemistry and physics at Penn State, where he began his academic career in 1989. His interdisciplinary research group includes chemists, physicists, biologists, materials scientists, mathematicians, electrical and mechanical engineers, and computer scientists. Their work focuses on the ultimate limits of miniaturization, exploring the atomic-scale chemical, physical, optical, mechanical, and electronic properties of surfaces and supramolecular assemblies. He and his students have developed new techniques to expand the applicability and chemical specificity of scanning probe microscopies. They have applied these and other tools to the study of catalysis, self- and directed assembly, and molecular and nanoscale devices. They work to advance nanofabrication down to ever smaller scales and greater chemical specificity in order to operate and to test functional molecular assemblies, and to connect these to the biological and chemical worlds. He develops multiplexed biomolecular sensor arrays for biomedical, neuroscience, and microbiome applications. He is developing new tools to measure the ocean microbiome and environment simultaneously.

Weiss has been awarded a NSF Presidential Young Investigator Award, the B. F. Goodrich Collegiate Inventors Award, a Sloan Fellowship, the ACS Nobel Laureate Signature Award for Graduate Education in Chemistry, a Guggenheim Fellowship, a NSF Creativity Award, and the ACS Award in Colloid and Surface Chemistry, among others. He was elected a fellow of: the American Association for the Advancement of Science, the American Physical Society, the American Vacuum Society, the ACS, the American Academy of Arts and Sciences, the American Institute for Medical and Biological Engineering, and an honorary fellow of the Chinese Chemical Society. He was a visiting professor at the University of Washington, Department of Molecular Biotechnology and Kyoto University, Electronic Science and Engineering Department and Venture Business Laboratory, and a distinguished visiting professor at the Kavli Nanoscience Institute and the Joint Center for Artificial Photosynthesis at Caltech. He is a visiting scholar at the Kavli Institute for Bionano Science & Technology and the Wyss Institute for Biologically Inspired Engineering at Harvard University (2015-16). He has been named the Institut National de la Recherche Scientifique (INRS) Chaire d’excellence Jacques¬Beaulieu at the Centre for Energy, Materials and Telecommunications. Weiss is the founding editor-in-chief of ACS Nano (2007-). At ACS Nano, he won the Association of American Publishers, Professional Scholarly Publishing PROSE Award for 2008, Best New Journal in Science, Technology, and Medicine, and ISI’s Rising Star Award a record ten times, and co-wrote the technology roadmap for the microbiome initiative.

Tools for the microbiome: Nano and beyond, J. S. Biteen, P. C. Blainey, M. Chun, G. M. Church, P. C. Dorrestein, S. E. Fraser, J. A. Gilbert, J. K. Jansson, R. Knight, J. F. Miller, A. Ozcan, K. A. Prather, E. G. Ruby, P. A. Silver, S. Taha, G. van den Engh, P. S. Weiss, G. C. L. Wong, A. T. Wright, and T. D. Young, ACS Nano 10, 6 (2016). DOI: 10.1021/acsnano.5b07826 – appears tomorrow

Printable ultrathin metal oxide semiconductor-based conformal biosensors, Y. S. Rim, S.-H. Bae, H. Chen, J. L. Yang, J. Kim, A. M. Andrews, P. S. Weiss, Y. Yang, and H. R. Tseng, ACS Nano 9, 12174 (2015).

Fabrication of high-performance ultrathin In2O3 film field-effect transistors and biosensors using chemical lift off lithography, J. Kim, Y. S. Rim, H. Chen, H. H. Cao, N. Nakatsuka, H. L Hinton, C. Zhao, A. M. Andrews, Y. Yang, and P. S. Weiss, ACS Nano 9, 4572 (2015).

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