Jake Lusis, PhDProfessor, Departments of Medicine, Cardiology, Human Genetics, Microbiology, Immunology & Molecular Genetics, UCLA
My PhD is in biophysics but somehow I ended up doing mouse genetics for my postdoc. I’m still doing mouse genetics, now with a focus on complex genetic traits, particularly those related to cardiovascular and metabolic disorders. With the development of high throughput technologies, such as expression arrays and sequencing, we have found it useful to marry such data with genetic analysis (‘systems genetics’). I also enjoy teaching.
Relevant Recent Publications
- Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472:57-63. PMCID:PMC3086762
- Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen S, Lusis AJ. (2013) Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 17:49-60. PMCID:PMC3771112
- Elin Org, Brian W. Parks, Jong Wha J Joo, Benjamin Emert, William Schwartzman, Eun Yong Kang, Margarete Mehrabian, Calvin Pan, Rob Knight, Robert Gunsalus, Thomas A. Drake, Eleazar Eskin, and Aldons J. Lusis. (2015) Genetic and environmental control of host-gut microbiota interactions. Genome Res., in press.
Active Funding in Microbiome-Related Research
|Funding Agency/Grant Number:||NIH PO1 HL28481|
|Title:||“Molecular genetic approaches in atherosclerosis research.”|
|Goals:||This program project is concerned with the identification and characterization of genetic factors contributing to energy homeostasis and metabolic disease. The emphasis is on combined human-mouse approaches.|